the secret is in our cells –

Aging is an irreversible natural process. Over the years, our body loses its vigor and the risk of contracting diseases increases. What if there was a chance to slow down aging, allowing us to live healthy lives for as long as possible?

In terms of combating oxidative stress and strengthening the immune system, many studies have been carried out which have followed different directions: from molecular chemistry to the mechanisms of autophagy to the study of the geographical areas where the life expectancy is highest, the so-called Blue areas like Loma Linda (California), Nicoya (Costa Rica), Ogliastra (Sardinia), Icaria (Greece) and Okinawa (Japan). The secret of the elixir of youth kept in these regions of the planet has been studied by positive biology, that is to say the science which does not focus on the cure of illnesses, but on the ability to age ” with success”.

From this research, the correlation between autophagy and cell regeneration appeared to be decisive. The mechanism of autophagy was identified by the Japanese researcher Yoshinori Ohsumi, who for this reason was awarded the 2016 Nobel Prize in Medicine. “Autophagy” literally means “to eat oneself”. Over time, in fact, the cells gradually accumulate many potentially toxic substances: these are molecular waste products, which increase with age.

If not “removed”, it can cause a chronic, silent state of inflammation and oxidative stress. What cleans cells? Precisely the process of autophagy, which over the years, however, loses its effectiveness. This process can be kept active in several ways, for example through medically supervised intermittent fasting, regular exercise and calorie restriction. But this is not the only way: studies indicate that tissue autophagy can be triggered by specific substances, including spermidine, produced by both the body’s cells and the intestinal microbiota. “Spermidine is a natural molecule present in various foods, in particular certain cereals – explains Lorenzo Galluzzi, professor at Weill Cornell Medical College in New York and member of the Scientific Advisory Board of Longevity Labs + – which has generated considerable interest for its antioxidant and autophagy activating qualities“. Vegetables, fruits and especially cheeses, especially if they are aged, are also rich in it. Spermidine is also full of Japanese natto, a dish made from fermented soybeans, while it falls to insignificant levels in meat.

Spermidine activates the genes responsible for the process of autophagy, responsible for the elimination of molecular waste that accumulates over time“, explains Professor Eugenio Luigi Iorio, surgeon, specialist in biochemistry and clinical chemistry, doctor of biochemical sciences, president of the International Observatory of Oxidative Stress and member of the Scientific Committee of the Italian Society of Multi-Specialty Regenerative Medicine and Surgery ( Simcri).”It can promote the elimination of toxic protein aggregates in neurons, a phenomenon associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease or amyotrophic lateral sclerosis, all of which are very debilitating. In addition, it improves cellular respiration, helps burn fat, has a hepatoprotective action and seems to be very important for the performance of the immune system.. ”

These properties have aroused the interest of researchers: according to Medline-Pubmed, the most prestigious biomedical database in the world, around 14,000 scientific works can be traced back to spermidine. Studies have shown a positive and significant correlation between the intake of spermidine, via diet or specific nutraceuticals, and favorable health effects, potentially useful for successful aging.

I’heterocephalous glabrousfor example, it is a small rodent that shows a lot of resistance to trauma, especially to skin wounds, and manages to live 32 years against the two of a common rodent: it should be noted that it is practically immune to diseases neuro-degenerative, cardiovascular and neoplastic, enough to be defined negligible aging, that is to say an animal with negligible aging. The secret seems to lie precisely in the high level of spermidine present in its cells.

There is also evidence of a relationship between health and spermidine intake in humans. The “Bruneck/Brunico” study, named after the town (in the province of Bolzano) where the subjects analyzed were recruited, confirmed the association between polyamine intake (and in particular spermidine) and longevity. The higher the level of polyamines consumed in the diet, the lower the cognitive impairment, the incidence of cardiovascular disease and the total mortality from cardiovascular and cancerous causes.

The study, carried out in close collaboration with Longevity Labs+, which identified a method for extracting spermidine from wheat germ (patented and natural method because only water-based). Spermidine, in fact, is difficult to extract because any action risks being too aggressive and harmful. Thanks to the research carried out by Madeo, it was possible to obtain a supplement, spermidineTHE LIFE Original 365+the first supplement rich in 100% natural spermidine available in Italy, safe because authorized by the European Food Safety Authority (Efsa) as Novel Food, enriched with zinc and vitamin B1 and capable of exerting an important antioxidant action .


April 1, 2022 (change April 1, 2022 | 19:03)



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